Clinical impact of abnormal gut flora in infants receiving parenteral nutrition.

摘要: Objective Illness is associated with the carriage of abnormal flora (aerobic Gram-bacilli except E. coli) in oropharynx and rectum. The aim this study was to investigate whether increased risk sepsis septicemia surgical newborn infants. Methods A 2-year prospective carried out on 94 consecutive infants requiring parenteral nutrition (PN) for gastrointestinal abnormalities. Throat rectal swabs were taken day 1 PN twice weekly. Patients divided into two groups: (AF; n = 41) normal (NF; 53). Sepsis defined as clinical features generalized inflammation blood culture. Septicemia combination positive Results Among carrying Pseudomonas Enterobacter spp. predominated. Duration (AF median 30 days; NF 9 days), incidence 29%; 6%), 22%; 2%) significantly greater group flora. Surveillance cultures allow detection a subset at high septicemia. degree gut dysfunction related severity underlying disease determines duration development association between may be because intestinal endotoxin pool known cause liver impairment consequent suppression systemic immunity.