Evaluation of a transplantable mouse brain tumour: a model for the study of human glioma
作者： G. J. Pilkington , J. L. Darling , P. L. Lantos
DOI: 10.1007/978-1-4613-2297-9_21
关键词: Molecular biology 、 Cell culture 、 In vivo 、 Glutamine synthetase 、 Cellular differentiation 、 Cell 、 Chemistry 、 In vitro 、 Glial fibrillary acidic protein 、 Adenosine
摘要: Three cell lines — VMDk P560, P540 and P497 derived from a transplantable spontaneous murine astrocytoma have been characterised in vitro vivo. The expressed astrocytic features, including the presence of glial fibrillary acidic protein (GFAP) glutamine synthetase (GS) showed an enhanced arborisation processes on exposure to dibutyryl adenosine 3′5′ cyclic monophosphate (dbcAMP). Transmission scanning electron microscopy revealed morphological differences their degree cellular differentiation. In growth properties cells correlated well with extent
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