Gastrointestinal Hormone in Dumping Syndrome and Reflux Esophagitis after Gastric Surgery

摘要: Several problems are associated with gastric resection, including the dumping syndrome, reflux esophagitis, and malabsorption. A better understanding of pathophysiological changes will shed light on new improved therapy. Serum levels seven circulating gastrointestinal hormones following a standardized solid meal brief score symptoms were evaluated in 10 patients after partial distal gastrectomy 12 total gastrectomy, both groups reconstructed by Billroth II anastomosis, 9 age-matched healthy controls. Patients underwent resection for cancer studied 45 +/- months surgery. At time study, had adapted well to surgery no longer exhibited severe seen immediately post-operatively. In contrast, esophagitis. The hormone could be divided into three patterns; obtunded responses (gastrin, PP), normal release (motilin, GIP) increased secretion (CCK, neurotensin, PYY). these, early reaction neurotensin correlated scores late syndrome literature, many have been shown respond as an enhancement rather than adaptation. other hormones, secretin belonged type enteroglucagon classified type. However, significance these hormonal remained uncertain. adaptive may help compensate loss motor function which accompanies resection. On hand, exacerbate esophageal gastrectomy.