Aldisine Alkaloids from the Philippine Sponge Stylissa massa Are Potent Inhibitors of Mitogen-Activated Protein Kinase Kinase-1 (MEK-1)
作者： Deniz Tasdemir , Robert Mallon , Michael Greenstein , Larry R. Feldberg , Steven C. Kim
DOI: 10.1021/JM0102856
关键词: MAPK cascade 、 Kinase 、 Chemistry 、 Mitogen-activated protein kinase kinase 、 Biochemistry 、 Enzyme inhibitor 、 Biological activity 、 Enzyme 、 Alkaloid 、 Mitogen-activated protein kinase
摘要: … MEK-1 inhibitory activity of hymenialdisine in the Raf/MEK-1/MAPK pathway. Our enzyme … the assay format used for Raf and MEK-1 kinase inhibition. The ELISA format for Raf-1 and …
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