Chronic intake of a high-cholesterol diet resulted in hepatic steatosis, focal nodular hyperplasia and fibrosis in non-obese mice.
作者： Maho Sumiyoshi , Masahiro Sakanaka , Yoshiyuki Kimura
DOI: 10.1017/S0007114509991772
关键词: Fibrosis 、 Endocrinology 、 Adipose tissue 、 Steatosis 、 Hepatic fibrosis 、 Fatty liver 、 Cholesterol 、 Blood lipids 、 Internal medicine 、 Focal nodular hyperplasia 、 Biology
摘要: We investigated the effects of a high-cholesterol (HC) diet administered long term (25 or 55 weeks) on metabolic disorders including hepatic damage in mice. The mice were fed HC (15 % milk fat, 1.5 cholesterol and 0.1 cholic acid, w/w) for 25 weeks. Body adipose tissue weights similar to those control diet. Consumption resulted hypercholesterolaemia, steatosis gallstones. In addition, focal nodular hyperplasia (FNH) mild fibrosis liver developed all Plasma levels monocyte chemoattractant protein (MCP)-1 elevated, level platelet-derived growth factor (PDGF)-B was increased compared with Thus, it seems likely that FNH caused by long-term consumption may be partly due an elevation plasma MCP-1 PDGF expression.
cabdirect.org
sci-hub.se 参考文章(47)
Roger Klein Moreira, None, Hepatic Stellate Cells and Liver Fibrosis Archives of Pathology & Laboratory Medicine. ,vol. 131, pp. 1728- 1734 ,(2007) , 10.1043/1543-2165(2007)131[1728:HSCALF]2.0.CO;2
Maho Sumiyoshi, Masahiro Sakanaka, Yoshiyuki Kimura, Chronic Intake of High-Fat and High-Sucrose Diets Differentially Affects Glucose Intolerance in Mice Journal of Nutrition. ,vol. 136, pp. 582- 587 ,(2006) , 10.1093/JN/136.3.582
A. M. Gressner, R. Weiskirchen, Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF‐β as major players and therapeutic targets Journal of Cellular and Molecular Medicine. ,vol. 10, pp. 76- 99 ,(2006) , 10.1111/J.1582-4934.2006.TB00292.X
J. George, D. Roulot, V. E. Koteliansky, D. M. Bissell, In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 12719- 12724 ,(1999) , 10.1073/PNAS.96.22.12719
Sumio Watanabe, Reiko Yaginuma, Kenichi Ikejima, Akihisa Miyazaki, Liver diseases and metabolic syndrome Journal of Gastroenterology. ,vol. 43, pp. 509- 518 ,(2008) , 10.1007/S00535-008-2193-6
P. Sartipy, D. J. Loskutoff, Monocyte chemoattractant protein 1 in obesity and insulin resistance Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 7265- 7270 ,(2003) , 10.1073/PNAS.1133870100
Hiroyuki Kobayashi, Takuya Tamatani, Tsuyoshi Tamura, Junichi Kusafuka, Hiroyuki Koga, Atsuyuki Yamataka, Geoffrey J. Lane, Katsumi Miyahara, Noriyoshi Sueyoshi, Takeshi Miyano, The role of monocyte chemoattractant protein-1 in biliary atresia Journal of Pediatric Surgery. ,vol. 41, pp. 1967- 1972 ,(2006) , 10.1016/J.JPEDSURG.2006.08.018
Jorge Plutzky, Emerging concepts in metabolic abnormalities associated with coronary artery disease. Current Opinion in Cardiology. ,vol. 15, pp. 416- 421 ,(2000) , 10.1097/00001573-200011000-00008
Masayuki Adachi, David A. Brenner, High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate–activated protein kinase† Hepatology. ,vol. 47, pp. 677- 685 ,(2008) , 10.1002/HEP.21991
Hitoshi Yoshiji, Shigeki Kuriyama, Ryuichi Noguchi, Yasuhide Ikenaka, Junichi Yoshii, Koji Yanase, Tadashi Namisaki, Mitsuteru Kitade, Masaharu Yamazaki, Kiyoshi Asada, Takemi Akahane, Tatsuhiro Tsujimoto, Masahito Uemura, Hiroshi Fukui, Amelioration of liver fibrogenesis by dual inhibition of PDGF and TGF-β with a combination of imatinib mesylate and ACE inhibitor in rats International Journal of Molecular Medicine. ,vol. 17, pp. 899- 904 ,(2006) , 10.3892/IJMM.17.5.899