Is platelet-derived growth factor-BB expression proportional to fibrosis in the hypertrophied lumber ligamentum flavum?
作者： Yu Zhang , Jianting Chen , Zhao-Ming Zhong , Dehong Yang , Qingan Zhu
DOI: 10.1097/BRS.0B013E3181F3D2DF
关键词: Lumbar spinal canal stenosis 、 Lumbar disc herniation 、 Muscle hypertrophy 、 Immunohistochemistry 、 Magnetic resonance imaging 、 Wound healing 、 Fibrosis 、 Pathology 、 Medicine 、 Blot
摘要: STUDY DESIGN A clinical and experimental assessment using human samples of lumbar ligamentum flavum (LF). OBJECTIVE To identify platelet-derived growth factor-BB (PDGF-BB) expression in hypertrophied LF patients with spinal canal stenosis (LSS) relate it to fibrosis. SUMMARY OF BACKGROUND DATA Recent studies showed that fibrosis hypertrophy was due accumulation inflammation-related scar tissue. PDGF-BB participates formation collagen development wound healing diseases. However, is unclear whether associated the LSS. METHODS In all, 10 LSS enrolled this study, while disc herniation (LDH) as a control group. thickness measured by axial T1-weighted magnetic resonance imaging. Fibrosis graded type identified. The location were analyzed immunohistochemical stains, real-time polymerase chain reaction, Western Blotting. Correlation among thickness, fibrosis, analyzed. RESULTS 5.3 ± 1.0 mm (range from 3.9 7.5 mm) group 2.8 0.7 1.69 3.8 LDH Obvious observed all group, correlated dural, middle, dorsal layers (P < 0.05), respectively. detected LF, particularly layer. higher than layer dural 0.05). mRNA significantly (r = 0.41) severity 0.69) CONCLUSION existed could be risk factor
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