Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

摘要: We have examined whether the extracellular matrix is a biochemical target for transforming growth factor-beta (TGFbeta). find that TGFbeta increases expression of major proteins, fibronectin and collagen. This effect general response to seen in primary cultures established lines cells from various types, normal transformed. The relative incorporation collagen into also TGFbeta. on levels as characterized chick embryo fibroblasts rapid, selective, persistent, specific, involves transcriptional events; it not mimicked by other factors tested. induction anchorage-independent specifically blocked inhibitors binding its cell surface receptor. results demonstrate functional involvement mediating cellular responses TGFbeta, suggest model action based control cells.