Signal Transduction Mechanisms Regulating Sperm Acrosomal Exocytosis

摘要: Publisher Summary This chapter reviews the signal transduction mechanisms regulating sperm acrosomal. The acrosome is a secretory vesicle overlying nucleus of mature spermatozoon. organelle product Golgi complex, and synthesized assembled during spermiogenesis. primary function acrosomal exocytosis following zona pellucida adhesion to permit penetration this unique extracellular matrix. matrix induced exocytotic reaction regulated event that displays discrete properties. A consequence development sharply defined, thin slit presumed result from limited digestion by acrosome-associated proteases. If capacitation necessary for spermatozoa undergo physiologically relevant in response pellucid, it reasonable both male female reproductive tracts could influence capacitation. Factors comprising tract fluids are thought bind stabilize plasma membrane, presumably prevent occurring. Other factors remove molecules surface, initiate process. Currently, understanding molecular mechanics at very early stage. Some general will be conserved with other systems, but clearly has properties distinguish these differences yield exciting results.