Central somatostatinergic regulation of growth hormone secretion in dwarf chickens.

作者: C.A Ahene , R.W Lea , S Harvey

DOI: 10.1016/0300-9629(91)90585-Z

关键词: Growth hormone secretionBiologyThyrotropin-releasing hormoneNeuropeptideSomatostatinInternal medicineBasal (phylogenetics)SecretionCentral nervous systemEndocrinologyHormone

摘要: 1. Basal circulating growth hormone (GH) concentrations in sex-linked-dwarf (SLD) chickens were unaffected by the intracerebroventricular (icv) injection of 10, 50 or 100 micrograms somatostatin (SRIF). 2. The GH response to systemic thyrotropin-releasing (TRH; 10 micrograms/kg, iv) was, however, 'paradoxically' enhanced 20 min after icv SRIF administration. 3. A lower dose (1.0 micrograms) had no effect on basal TRH-induced release. 4. High-titre antisera (4 microliters) also acute plasma concentrations, but augmented TRH challenge. 5. would appear act at central sites modulate stimulated secretion SLD chickens.

参考文章(36)
L. M. Huybrechts, D. B. King, T. J. Lauterio, J. Marsh, C. G. Scanes, Plasma concentrations of somatomedin-C in hypophysectomized, dwarf and intact growing domestic fowl as determined by heterologous radioimmunoassay Journal of Endocrinology. ,vol. 104, pp. 233- 239 ,(1985) , 10.1677/JOE.0.1040233
G.S.G. Spencer, S. Harvey, A.R.S. Audsley, K.G. Hallett, S. Kestin, The effect of immunization against somatostatin on growth rates and growth hormone secretion in the chicken. Comparative Biochemistry and Physiology Part A: Physiology. ,vol. 85, pp. 553- 556 ,(1986) , 10.1016/0300-9629(86)90445-7
Jacques Epelbaum, Lucia Tapia-Arancibia, Gérard Alonso, Hélène Astier, Claude Kordon, The Anterior Periventricular Hypothalamus Is the Site of Somatostatin Inhibition on Its Own Release: An in vitro and Immunocytochemical Study Neuroendocrinology. ,vol. 44, pp. 255- 259 ,(1986) , 10.1159/000124653
YOSHIHISA HASEGAWA, KAORU MIYAMOTO, MITSUO NOMURA, MASAO IGARASHI, KENJI KANGAWA, HISAYUKI MATSUO, Isolation and amino acid compositions of four somatostatin-like substances in chicken hypothalamic extract. Endocrinology. ,vol. 115, pp. 433- 435 ,(1984) , 10.1210/ENDO-115-1-433
S. Harvey, D. Attardo, J. S. Baidwan, Somatostatin binding to chicken adenohypophysial membranes. Journal of Molecular Endocrinology. ,vol. 4, pp. 213- 221 ,(1990) , 10.1677/JME.0.0040213
R. W. Lea, S. Harvey, Feedback effects of growth hormone on anterior pituitary function in chickens Journal of Endocrinology. ,vol. 125, pp. 409- 415 ,(1990) , 10.1677/JOE.0.1250409