miRNA-34a underexpressed in Merkel cell polyomavirus-negative Merkel cell carcinoma.

摘要: Merkel cell polyomavirus (MCV) is frequently detectable in carcinoma (MCC) tumors, but the significance of MCV infection not yet totally understood. Thus far, no key regulatory miRNA has been identified for MCC tumorigenesis. However, distinct expression profiles have suggested MCV-positive and MCV-negative tumors. We used microarray hybridization to identify differences tumor samples according status further validated these results by quantitative reverse transcription polymerase chain reaction (qRT-PCR). When compared with we detected overexpression miR-34a, miR-30a, miR-142-3p, miR-1539 those positives. In addition, slight underexpression was tumors miR-181d. confirmed miRNAs statistically significant miR-34a both array analysis qRT-PCR. Neither location nor development metastases affected expression.