Liver Disease: A Neglected Complication of Diabetes Mellitus

作者: Marco Arrese , Juan Pablo Arab , Juan Pablo Arancibia , Roberto Candia , Arnoldo Riquelme

DOI: 10.1016/B978-0-12-385083-6.00023-1

关键词: SteatohepatitisFatty liverGastroenterologyMetabolic syndromeInternal medicineCirrhosisMedicineLiver diseaseDiabetes mellitusType 2 Diabetes MellitusHepatic Complication

摘要: : Type 2 diabetes mellitus (T2DM) is strongly associated with liver fat accumulation leading to the so-called non-alcoholic fatty disease (NAFLD). In last two decades, it has been recognized that a proportion of patients NAFLD may develop progressive form called steatohepatitis (NASH) which lead cirrhosis, end-stage complications and risk developing hepatocellular carcinoma. now considered hepatic manifestation metabolic syndrome T2DM being clear factor for NASH cirrhosis development. Here, current concepts on its association are reviewed. Current knowledge suggests exhibit an increased awareness should be enhanced among health providers involved in diabetes. Finally, screening disorders part routine evaluation T2DM.

参考文章(51)
Helena Cortez-Pinto, Amélia Baptista, Maria Ermelinda Camilo, Miguel Carneiro de Moura, Nonalcoholic steatohepatitis--a long-term follow-up study: comparison with alcoholic hepatitis in ambulatory and hospitalized patients. Digestive Diseases and Sciences. ,vol. 48, pp. 1909- 1913 ,(2003) , 10.1023/A:1026152415917
Norberto C Chavez-Tapia, Felix I Tellez-Avila, Tonatiuh Barrientos-Gutierrez, Nahum Mendez-Sanchez, Javier Lizardi-Cervera, Misael Uribe, Bariatric surgery for non-alcoholic steatohepatitis in obese patients. Cochrane Database of Systematic Reviews. ,vol. 2010, ,(2010) , 10.1002/14651858.CD007340.PUB2
Joel E Lavine, Jeffrey B Schwimmer, Jean P Molleston, Ann O Scheimann, Karen F Murray, Stephanie H Abrams, Philip Rosenthal, Arun J Sanyal, Patricia R Robuck, Elizabeth M Brunt, Aynur Ünalp, James Tonascia, NASH CRN Research Group, None, Treatment of nonalcoholic fatty liver disease in children: TONIC trial design. Contemporary Clinical Trials. ,vol. 31, pp. 62- 70 ,(2010) , 10.1016/J.CCT.2009.09.001
C MATTEONI, Z YOUNOSSI, T GRAMLICH, N BOPARAI, Y LIU, A MCCULLOUGH, Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology. ,vol. 116, pp. 1413- 1419 ,(1999) , 10.1016/S0016-5085(99)70506-8
Mariana Lazo, Jeanne Clark, The epidemiology of nonalcoholic fatty liver disease: a global perspective. Seminars in Liver Disease. ,vol. 28, pp. 339- 350 ,(2008) , 10.1055/S-0028-1091978
Leon A. Adams, Nonalcoholic fatty liver disease and diabetes mellitus. Endocrine Research. ,vol. 32, pp. 59- 69 ,(2007) , 10.1080/07435800701743885
Les Lang, Pioglitazone trial for NASH: results show promise. Gastroenterology. ,vol. 132, pp. 836- 838 ,(2007) , 10.1053/J.GASTRO.2007.02.024
Etsuko Hashimoto, Geoffrey C Farrell, Will non-invasive markers replace liver biopsy for diagnosing and staging fibrosis in non-alcoholic steatohepatitis? Journal of Gastroenterology and Hepatology. ,vol. 24, pp. 501- 503 ,(2009) , 10.1111/J.1440-1746.2009.05806.X
Abby B. Siegel, Andrew X. Zhu, Metabolic syndrome and hepatocellular carcinoma: two growing epidemics with a potential link. Cancer. ,vol. 115, pp. 5651- 5661 ,(2009) , 10.1002/CNCR.24687
Jayant A. Talwalkar, Meng Yin, Jeff L. Fidler, Schuyler O. Sanderson, Patrick S. Kamath, Richard L. Ehman, Magnetic resonance imaging of hepatic fibrosis: emerging clinical applications. Hepatology. ,vol. 47, pp. 332- 342 ,(2007) , 10.1002/HEP.21972