Histaminergic afferent system in the cerebellum: structure and function

摘要: Histaminergic afferent system of the cerebellum, having been considered as an essential component direct hypothalamocerebellar circuits, originates from tuberomammillary nucleus in hypothalamus. Unlike mossy fibers and climbing fibers, histaminergic a third type cerebellar afferents, extend fine varicose throughout cortex nuclei. Histamine receptors, belonging to family G protein-coupled are widely present cerebellum. Through these histamine directly excites Purkinje cells granule cortex, well nuclear neurons. Therefore, afferents parallelly modulate dominant components circuitry consequently influence final output In this way, actively participates cerebellum-mediated motor balance coordination nonsomatic functions. Accordingly, reagents may become potential drugs for clinical treatment ataxia other disease. On hand, considering hypothalamus is high regulatory center autonomic visceral activities, fibers/projections, bridging somatic structure, play critical role somatic-nonsomatic integration.