Jacalin: an IgA-binding lectin.

摘要: We previously reported that seeds of Artocarpus integrifolia (jackfruit) contain a lectin, which we call jacalin, is both potent T cell mitogen and an apparently cell-independent activator human B cells for the secretion immunoglobulins. During above experiments noted massive precipitation in cultures stimulated with greater than or equal to 100 micrograms lectin. In this paper, show precipitate formed after interaction jacalin serum protein added culture medium. More importantly, demonstrate IgA probably major constituent precipitated by lectin no IgG IgM can be detected precipitates. secretions such as colostrum, only jacalin. On basis specificity describe simple reliable affinity chromatography procedure purification colostrum IgA. Jacalin D-Gal binding should useful tool studying secretory