Muscarinic Receptors in Airways Diseases

摘要: What are the different muscarinic acetylocholine receptor subtypes and how they distributed in airways molecular signalling mechanisms? is their function inflammatory mechanisms neurogenic non-neurogenic control of airways? How gene expression regulated? The importance receptors for pathophysiology treatment chronic obstructive diseases calls a comprehensive integrated overview knowledge to address such questions, discuss role these as asthma COPD, present novel perspectives on antimuscarinic drug development. This book seeks meet this need. It points out innovative insights into hitherto poorly understood postjunctional M2 airway smooth muscle contraction sheds some light concepts development, with special reference long-acting M3 M1 receptor-selective antagonist tiotropium bromide. modulation cholinergic vagal nerve activity by pathways dealt emphasis laid potential COPD. pulmonologists medical, physiological pharmacological scientists involved research, whom it offers an update recent developments physiology, pathophysiology, pharmacology therapeutics system scientific basis further research field.