Development and evaluation of an inhibitor-releasing matrix for intrauterine devices
作者： J.W. Burns , J.C. Goodpasture , P. Friel , R. Wheeler , L.J.D. Zaneveld
DOI: 10.1016/0010-7824(82)90151-2
关键词: Matrix (biology) 、 Aprotinin 、 In vitro 、 Pharmacology 、 In utero 、 Gynecology 、 Molecular mass 、 Incubation 、 Medicine 、 Tranexamic acid 、 Antifibrinolytic agent
摘要: Abstract Antifibrinolytic agents when released into the uterine cavity decrease menorrhagia associated with IUD use. Our objective was to develop a matrix that could be incorporated onto an and release anti-fibrinolytic agents. The copolymer ethylene-vinyl acetate (EVA) selected for detailed study because it has advantage over other materials in can large molecular weight substances more than 100 days, allows incorporation of amounts different weights. Two compounds, tranexamic acid (AMCA, MW = 157) Trasylol (Kunitz pancreatic trypsin inhibitor, 6,500) were EVA their rates measured. In vitro studies AMCA showed after initial burst, constant high rate obtained prolonged period time. utero from rabbits similar . By contrast, decreased low levels during incubation however, appeared higher
elsevier.com
sci-hub.se 参考文章(16)
Amiya B. Kar, Amy D. Engineer, Rashmi Goel, V.P. Kamboj, P.R. Dasgupta, S.R. Chowdhury, Effect of an intrauterine contraceptive device on biochemical composition of uterine fluid. American Journal of Obstetrics and Gynecology. ,vol. 101, pp. 966- 970 ,(1968) , 10.1016/0002-9378(68)90283-4
S.T. Shaw, D.L. Moyer, D.E. Aaronson, J. Underwood, R.V. Forino, Intrauterine medication with epsilon aminocaproic acid Contraception. ,vol. 11, pp. 395- 407 ,(1975) , 10.1016/0010-7824(75)90002-5
Lennart Nilsson, Göran Rybo, Treatment of menorrhagia American Journal of Obstetrics and Gynecology. ,vol. 110, pp. 713- 720 ,(1971) , 10.1016/0002-9378(71)90259-6
S. T. SHAW, R. W. CIHAK, D. L. MOYER, Fibrin proteolysis in the monkey uterine cavity: variations with and without IUD. Nature. ,vol. 228, pp. 1097- 1099 ,(1970) , 10.1038/2281097A0
Ole K. Albrechtsen, Preben Skjødt, THE EFFECT OF EPSILON-AMINOCAPROIC ACID ON UTERINE HAEMORRHAGE. Acta Obstetricia et Gynecologica Scandinavica. ,vol. 42, pp. 160- 180 ,(1963) , 10.3109/00016346309157878
R. LANGER, INVITED REVIEW POLYMERIC DELIVERY SYSTEMS FOR CONTROLLED DRUG RELEASE Chemical Engineering Communications. ,vol. 6, pp. 1- 48 ,(1980) , 10.1080/00986448008912519
S. L. T. Callender, G. T. Warner, E. Cope, Treatment of Menorrhagia with Tranexamic Acid. A Double-blind Trial BMJ. ,vol. 4, pp. 214- 216 ,(1970) , 10.1136/BMJ.4.5729.214
ROBERT LANGER, JUDAH FOLKMAN, Polymers for the sustained release of proteins and other macromolecules Nature. ,vol. 263, pp. 797- 800 ,(1976) , 10.1038/263797A0
Bertil Larsson, Percy Liedholm, Nils-Otto Sjöberg, Birger Åstedt, Increased fibrinolytic activity in the endometrium of patients using copper-IUD Contraception. ,vol. 9, pp. 531- 537 ,(1974) , 10.1016/0010-7824(74)90064-X
William D. Rhine, Dean S.T. Hsieh, Robert Langer, Polymers for Sustained Macromolecule Release: Procedures to Fabricate Reproducible Delivery Systems and Control Release Kinetics Journal of Pharmaceutical Sciences. ,vol. 69, pp. 265- 270 ,(1980) , 10.1002/JPS.2600690305