Intrauterine medication with epsilon aminocaproic acid

摘要: Abstract Menstrual blood loss was quantitated in a group of rhesus monkeys before and after intrauterine insertions silicone rubber devices alone, polyethylene plus devices. Silicone used as the carrier epsilon aminocaproic acid (EACA) order to provide sustained drug release utero . without EACA were control A beneficial effect medication with on uterine hemorrhage demonstrated wearing (IUDs). With nonmedicated MBL increased 96% over preinsertion values, whereas EACA-releasing resulted only 33% increase, during first menstrual period insertion. Mean volume 109% values (baseline) animals IUDs alone 132% baseline those devices; whereas, average 44% Neither localized or disseminated intravascular coagulation resulting from detectable by assay circulating levels fibrinogen, plasminogen, fibrin-fibrinogen degradation products.