MicroRNA-19b is a potential biomarker of increased myocardial collagen cross-linking in patients with aortic stenosis and heart failure.
作者： Javier Beaumont , Begoña López , Susana Ravassa , Nerea Hermida , Gorka San José
DOI: 10.1038/SREP40696
关键词: Heart failure 、 Internal medicine 、 Fibrosis 、 Aortic valve stenosis 、 Medicine 、 Collagen network 、 Cardiology 、 Connective tissue 、 Stenosis 、 Lysyl oxidase 、 Biomarker (medicine)
摘要: This study analyzed the potential associations of 7 myocardial fibrosis-related microRNAs with quality collagen network (e.g., degree fibril cross-linking or CCL) and enzyme lysyl oxidase (LOX) responsible for CCL in 28 patients severe aortic stenosis (AS) whom 46% had a diagnosis chronic heart failure (HF). MicroRNA expression was blood samples. From studied only miR-19b presented direct correlation (p < 0.05) between serum myocardium. Compared to controls both were reduced (p < 0.01) AS patients. In addition, myocardium HF compared without HF. Myocardial inversely correlated LOX, LV stiffness vitro studies inhibition increased connective tissue growth factor protein LOX human fibroblasts. conclusion, decreased may be involved up-regulation excessive CCL, consequently patients, namely those Serum can biomarker these alterations particularly
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