Potential Role of CD133 Expression in the Susceptibility of Human Liver Cancer Stem-Like Cells to TRAIL.

摘要: Hepatocellular carcinoma (HCC) is one of the most common malignancies, with a poor prognosis and high recurrence rate. In present study, we identified CD133, markers cancer stem cells, as novel molecular target tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). four human HCC cell lines established from primary tumors, found that CD133-high liver stem-like cells (CD133hi) derived SNU-475 line were highly susceptible to TRAIL compared other small population CD133. CD133hi showed upregulation receptor DR5 stemness-related genes such c-Myc ABC transporters their CD133-low (CD133lo) cells. Hypersensitivity was associated c-Myc-mediated downregulation c-FLIPL in Knockdown CD133 expression resulted c-Myc, depletion caused decrease surface an increase and, consequently, attenuated TRAIL-induced cytotoxicity apoptosis These results suggest may provide new strategy for CSCs HCC-targeted therapies potentially, CD133-expressing types cancer.