Validation of the new AJCC TNM staging system for gastric cancer in a large cohort of patients (n = 2,155): Focus on the T category

摘要: Abstract Background The prognostic value of T subclassification in patients with gastric carcinoma has been just implemented the new AJCC TNM staging system, which reclassified T2a and T2b into T2 T3 tumors, respectively. aim present study was to validate significance categorization within frame latest system. Methods We retrospectively reviewed records 686 T2/T3 among 2155 subjects who underwent radical resection for at six Italian centers from 1988 through 2006. Results Upon multivariate analysis, categories, extent lymph node dissection (D) patient's age were retained by survival model as independent factors. In particular, death risk tumors higher than that (HR: 1.42, P  = 0.005). Among previously classified having disease 270 (39.4%) 416 (60.6%), After a median follow-up 55 months, 5-year overall rates 67.3% 52.3% respectively (  = 0.0154 Conclusions Our data confirm difference between newly proposed should be routine clinical practice improve stratification cancer.