Increasing the Effectiveness of Vaginal Microbicides: A Biophysical Framework to Rethink Behavioral Acceptability

摘要: Background: Microbicide candidates delivered via gel vehicles are intended to coat the vaginal epithelium after application. The coating process depends on intrinsic biophysical properties of texture, which restricts potential choices for an effective product: first must be physically synthesizable, then acceptable user, and finally applied in a manner promoting timely adequate coating, so that user adherence is optimized. We present conceptual framework anchoring microbicide behavioral acceptability within fulfillment product requirements. Methods: conducted semi-qualitative/quantitative study targeting women aged 18–55 Northern California assess preferences attributes. Attributes included: (i) wait time between application intercourse, (ii) texture (iii) trade-off texture. Wait times were assessed using mathematical model determining rates depending upon gel’s physical Results: 71 participated. Results suggest would independently prefer spreading rapidly, 2 15 minutes (P,0.0001), as well one thick or slippery (P,0.02). Clearly, gels do not spread rapidly; hence motivation trade-off. When asked same question ‘constrained’ by reality, indicated no significant preference particular thickness (and therefore waiting time) (P.0.10) use with steady partner, watery rapidly rather than having intermediate casual partner (P=0.024). Conclusions: Biophysical constraints alter women’s regarding Product developers should offer range formulations order address all preferences. designed rethink terms requirements can help improve ultimately enhancing effectiveness.