Optimization of formulation processes using Design Expert® Software for preparation of polymeric blends-artesunate-amodiaquine HCl microparticles

摘要: Abstract A 2 3 Factorial design of cissus-gelatin B polymer blends was developed to formulate amodiaquine HCl-artesunate (AQ-AS) microparticles by varying the blend concentration (2 %w/v, 5 %w/v), crosslinking time (0.5 h, 1 h) and glutaraldehye volume (0.5 ml, 1 ml). The formulations were evaluated using drug entrapment efficiency (EE), particle size, polydispersity index, thermal behavior with differential scanning calorimetry, crystallinity powder X-ray diffraction, morphology electron microscope in vitro release combination simulated gastric fluid (SGF, pH = 7.4, 95%) methanol (5%). expected responses, EE fitted into Design Expert ® . exhibited pseudoplastic there no marked change in rheology 2% w/v dispersion at 55 °C. AQ-AS formulated dark brownish discrete mass, physically stabilized, irregular shape, polydisperse, partially crystalline system. An optimal formulation comprising (5 glutaraldehyde (1 ml) cross-linking (0.5 h) identified provide desired values for EE, amodaquine HCl (47.41%), artesunate (36.42%) release. This study proposes best opportunity selection factors required optimum drugs.