Cause and course in a series of patients with sporadic chorea.

摘要: Objective: To identify correlations between clinical and neuroimaging features in sporadic chorea to explicate the evolution of choreas differing aetiologies. Methods: We analysed data 51 consecutive cases (17 males, 34 females; age 16–95 years) admitted neurology departments two general hospitals from January 1994 December 1999, neurological institutes 1997. Six months later patients were reassessed clinically those still with (20 cases) asked undergo genetic tests for Huntington's disease dentatorubropallidoluysian atrophy. Results: There 9 focal dyskinesias, 18 hemichorea, 24 generalised chorea; onset was acute 17, subacute 27, insidious seven. Analysis permitted classification as follows: vascular-related (21 cases); vasculitis (1 case); hypoxia (2 drug-induced (7 AIDS-related (5 cases), borreliosis Sydenham's hyperglycaemia hyponatraemia (HD) acanthocytosis case). In 3 neither etiological factors nor neuroradiological alterations found. Conclusions: Although a convincing concordance choreic signs findings possible 4 only, it assign an aetiology most vascular related causes frequent metabolic often participating. is not unusual cause choreas. HIV infection emerging should be considered young presenting without family history movement disorders. emphasize importance follow-up persistent which testing mandatory.