Pulmonary Fibrosis after Prolonged Therapy with 1,3-Bis (2-chloroethyl)-nitrosourea
作者： David Crittenden , Bill L. Tranum , Arthur Haut
关键词: Chemotherapy 、 Metastatic malignant melanoma 、 Complete remission 、 Pulmonary fibrosis 、 Imidazole carboxamide 、 Cytotoxic T cell 、 Nitrosourea 、 Medicine 、 Pathology 、 Nitrosourea Compound
摘要: A 43-year-old man with metastatic malignant melanoma was treated l,3-bis(2-chloroethyl)-l-mtrosoiirea (BCNU) in combination imidazole carboxamide and hydroxyurea. He achieved complete remission. After 22 months of chemotherapy, the patient developed bilateral pulmonary infiltrates. Open lung biopsy showed sclerosing alveolitis. Long-term therapy BCNU may cause fibrosis, as has been seen other cytotoxic drugs.
sci-hub.se 参考文章(11)
Stephen K. Carter, Frank M. Schabel, Lawrence E. Broder, Thomas P. Johnston, 1,3-Bis(2-Chloroethyl)-1-Nitrosourea (Bcnu) And Other Nitrosoureas In Cancer Treatment: A Review Advances in Cancer Research. ,vol. 16, pp. 273- 332 ,(1972) , 10.1016/S0065-230X(08)60343-7
Sheldon P. Rothenberg, Thomas S. Cottrell, Arthur A. Topilow, Interstitial pneumonia after prolonged treatment with cyclophosphamide. The American review of respiratory disease. ,vol. 108, pp. 114- ,(2015) , 10.1164/ARRD.1973.108.1.114
Bonnie J. Bowdon, Glynn P. Wheeler, Some Effects of 1, 3-Bis(2-chloroethyl)-1-nitrosourea upon the Synthesis of Protein and Nucleic Acids in Vivo and in Vitro Cancer Research. ,vol. 25, pp. 1770- 1778 ,(1965)
Herman Oliner, Robert Schwartz, Fernando Rubio, William Dameshek, Interstitial pulmonary fibrosis following busulfan therapy The American Journal of Medicine. ,vol. 31, pp. 134- 139 ,(1961) , 10.1016/0002-9343(61)90229-7
Pelagio V. Iriarte, Juliet Hananian, Jean A. Cortner, Central nervous system leukemia and solid tumors of childhood:Treatment with 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) Cancer. ,vol. 19, pp. 1187- 1194 ,(1966) , 10.1002/1097-0142(196609)19:9<1187::AID-CNCR2820190902>3.0.CO;2-T
Albert M. Clarysse, Pulmonary Disease Complicating Intermittent Therapy With Methotrexate JAMA: The Journal of the American Medical Association. ,vol. 209, pp. 1861- 1864 ,(1969) , 10.1001/JAMA.1969.03160250017003
Sachidananda Shastri, Robert E. Slayton, Janet Wolter, Charles P. Perlia, Samuel G. Taylor, Clinical study with bleomycin. Cancer. ,vol. 28, pp. 1142- 1146 ,(1971) , 10.1002/1097-0142(1971)28:5<1142::AID-CNCR2820280509>3.0.CO;2-A
John J. Costanzi, V. K. Vaitkevicius, Joseph M. Quagliana, Barth Hoogstraten, Charles A. Coltman, Fred C. Delaney, Combination chemotherapy for disseminated malignant melanoma Cancer. ,vol. 35, pp. 342- 346 ,(1975) , 10.1002/1097-0142(197502)35:2<342::AID-CNCR2820350207>3.0.CO;2-F
E. C. ROSENOW, The Spectrum of Drug-Induced Pulmonary Disease Annals of Internal Medicine. ,vol. 77, pp. 977- 991 ,(1972) , 10.7326/0003-4819-77-6-977
LEE N. PODOLL, STEFAN S. WINKLER, Busulfan lung. Report of two cases and review of the literature. American Journal of Roentgenology. ,vol. 120, pp. 151- 156 ,(1974) , 10.2214/AJR.120.1.151