Apolipoprotein(a) isoform-specific changes of lipoprotein(a) after kidney transplantation.

摘要: The atherogenic lipoprotein(a) (Lp(a)) is significantly increased in patients with kidney disease. Some studies hemodialysis described this increase to be dependent on the genetic apolipoprotein(a) (apo(a)) isoforms. Only who express high molecular weight (HMW) apo(a) isoforms but not those low (LMW) show a relative of Lp(a) when compared healthy controls matched for However, was confirmed by all studies. We therefore prospectively investigated changes deriving from each isoform heterozygotes following transplantation. concentrations were measured ELISA. To calculate isoform-specific and isoform, we densitometrically scanned bands immunoblots before after transplantation 20 expressing two Of these, 10 expressed both an LMW HMW isoform. other only Densitometric scanning calculation isoform-derived clearly demonstrated that decrease caused expression In some patients, observed almost complete disappearance This study demonstrates plasma disease depend genetically determined size apo(a). provides evidence interaction variability function concentrations.