Influence of hematocrit on the measurement of lipoproteins demonstrated by the example of lipoprotein(a)

摘要: Influence of hematocrit on the measurement lipoproteins demonstrated by example lipoprotein(a). Background The many parameters human blood is usually performed in plasma or serum. Since apolipoproteins, for example, are found almost exclusively fraction after low-speed centrifugation, these can be expected to distributed a different volume depending value. Therefore, measured levels might relatively too low high comparison whole concentrations case abnormal levels. aim our experiments was evaluate extent differences between and concentrations, taking as an lipoprotein(a) [Lp(a)] hemodialysis patients with documented decreased values. Methods Lp(a) well 15 values (0.29 ± 0.02) 11 control subjects (0.45 0.04). Results Plasma were 27% higher than controls (19.7 vs. 15.5mg/dl). relative difference twice (59%) when (13.5 8.5mg/dl). Similar observed 125 256 calculated formula \[ L p \( \) pasma * 1 − h e m t o c r i \] . Conclusions Our findings clearly demonstrate that strong confounding variable lipoprotein epidemiological studies plasma, especially cases Furthermore, investigating longitudinal changes should consider potential changes.