Autophagy Modulation by Lanthionine Ketimine Ethyl Ester Improves Long-Term Outcome after Central Fluid Percussion Injury in the Mouse

摘要: Abstract Diffuse axonal injury is recognized as a progressive and long-term consequence of traumatic brain injury. Axonal can have sustained negative consequences on neuronal functions such anterograde retrograde transport cellular processes autophagy that depend cytoarchitecture axon integrity. These changes lead to somatic atrophy an inability repair promote plasticity. Obstruction the autophagic process has been noted after injury, rapamycin, drug used stimulate autophagy, demonstrated positive effects in models. The optimization drugs beneficial without side could be attenuate improved outcome. Lanthionine ketimine ethyl ester, bioavailable derivative natural sulfur amino acid metabolite, both vitro vivo. Thirty minutes moderate central fluid percussion throughout ...