Tumor-associated proteolysis and prognosis: new functional risk factors in gastric cancer defined by the urokinase-type plasminogen activator system.
作者： M M Heiss , R Babic , H Allgayer , K U Gruetzner , K W Jauch
DOI: 10.1200/JCO.1995.13.8.2084
关键词: Cancer 、 Oncology 、 Stomach 、 Plasminogen activator 、 Risk factor 、 Epithelioma 、 Medicine 、 Urokinase 、 Pathology 、 Carcinoma 、 Metastasis 、 Internal medicine
摘要: PURPOSEThe significance of tumor-associated proteolysis as reflected by parameters the urokinase-type plasminogen activator (uPA) system for prognosis in cancer patients has been proposed because evidence its central role basic mechanisms invasion and metastasis. The aim present study was to evaluate whether expression uPA might be clinical value gastric a tumor/biologically defined risk factor.PATIENTS AND METHODSIn consecutive series 203 resected primary cancer, uPA, uPA-receptor (uPA-R), inhibitor (PAI)-1, PAI-2 determined immunohistochemically. results were classified semiquantitatively (0 3). Patients followed-up prospectively median 31 months (range, 9 56 months). Disease-free overall survival analyzed according Kaplan-Meier with univariate multivariate Cox analyses relation conventional prognostic factors.RESULTSUniv...
sci-hub.se 参考文章(35)
Jari Pöllänen, Ross W. Stephens, Antti Vaheri, Directed Plasminogen Activation at the Surface of Normal and Malignant Cells Advances in Cancer Research. ,vol. 57, pp. 273- 328 ,(1991) , 10.1016/S0065-230X(08)61002-7
M.V. Cubellis, T.C. Wun, F. Blasi, Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1. The EMBO Journal. ,vol. 9, pp. 1079- 1085 ,(1990) , 10.1002/J.1460-2075.1990.TB08213.X
Lance A. Liotta, Tumor Invasion and Metastases—Role of the Extracellular Matrix: Rhoads Memorial Award Lecture Cancer Research. ,vol. 46, pp. 1- 7 ,(1986)
William Hollas, Douglas Boyd, Francesco Blasi, Role of the urokinase receptor in facilitating extracellular matrix invasion by cultured colon cancer. Cancer Research. ,vol. 51, pp. 3690- 3695 ,(1991)
E. Bianchi, I. F. Mizukami, D. A. Lawrence, H. S. Smith, B. M. Ljung, M. A. Shuman, R. L. Cohen, R. F. Todd, A. T. Thor, The Urokinase Receptor Is Expressed in Invasive Breast Cancer but not in Normal Breast Tissue Cancer Research. ,vol. 54, pp. 861- 866 ,(1994)
David R. Cox, Regression Models and Life-Tables Springer Series in Statistics. ,vol. 34, pp. 527- 541 ,(1992) , 10.1007/978-1-4612-4380-9_37
Ulrich Fink, Jürgen D. Roder, Jörg R. Siewert, Karen Becker, Manfred Schmitt, Hjalmar Nekarda, Holger Vogelsang, Kurt Ulm, Andrea Wenninger, Prognostic Impact of Urokinase-type Plasminogen Activator and Its Inhibitor PAI-1 in Completely Resected Gastric Cancer Cancer Research. ,vol. 54, pp. 2900- 2907 ,(1994)
J Mimuro, D J Loskutoff, Binding of type 1 plasminogen activator inhibitor to the extracellular matrix of cultured bovine endothelial cells. Journal of Biological Chemistry. ,vol. 264, pp. 5058- 5063 ,(1989) , 10.1016/S0021-9258(18)83699-7
Kell Østerlind, Nils Brünner, Keld Danø, Jan Grøndahl-Hansen, Helle Pedersen, Dorte Francis, Heine Høi Hansen, Urokinase and Plasminogen Activator Inhibitor Type 1 in Pulmonary Adenocarcinoma Cancer Research. ,vol. 54, pp. 120- 123 ,(1994)
L C Petersen, L R Lund, L S Nielsen, K Danø, L Skriver, One-chain urokinase-type plasminogen activator from human sarcoma cells is a proenzyme with little or no intrinsic activity. Journal of Biological Chemistry. ,vol. 263, pp. 11189- 11195 ,(1988) , 10.1016/S0021-9258(18)37940-7