Matrix Metalloproteinase-9 Is Involved in Chronic Lymphocytic Leukemia Cell Response to Fludarabine and Arsenic Trioxide
作者： Irene Amigo-Jiménez , Elvira Bailón , Estefanía Ugarte-Berzal , Noemí Aguilera-Montilla , José A. García-Marco
DOI: 10.1371/JOURNAL.PONE.0099993
关键词: Medicine 、 HEK 293 cells 、 Chronic lymphocytic leukemia 、 Arsenic trioxide 、 Cell migration 、 Immunology 、 Chemotherapy 、 Leukemia 、 Cytotoxic T cell 、 Fludarabine 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: Background Matrix metalloproteinase-9 (MMP-9) contributes to chronic lymphocytic leukemia (CLL) pathology by regulating cell migration and preventing spontaneous apoptosis. It is not known if MMP-9 involved in CLL response chemotherapy we address this the present study, using arsenic trioxide (ATO) fludarabine as examples of cytotoxic drugs.
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