Bacterial- and viral-induced inflammation increases sensitivity to acetaminophen hepatotoxicity.

作者: Jane F. Maddox , Chidozie J. Amuzie , Maoxiang Li , Sandra W. Newport , Erica Sparkenbaugh

DOI: 10.1080/15287390903249057

关键词: Tumor necrosis factor alphaCentrilobular necrosisLiver injuryViral hepatitisAcetaminophenInflammationDose–response relationshipPharmacologyLipopolysaccharideImmunologyMedicine

摘要: … occurred earlier and was significantly greater than control by 3 … ALT was significantly increased in the co-treated group, the … remained viable in livers of APAP-treated mice for at least 24 …

参考文章(57)
DAVID M. ROSENBERG, ALBERT A. MEYER, ISAAC H. MANNING, FRANCIS A. NEELON, Acetaminophen and hepatic dysfunction in infectious mononucleosis. Southern Medical Journal. ,vol. 70, pp. 660- 661 ,(1977) , 10.1097/00007611-197706000-00007
M L Nibert, R L Margraf, K M Coombs, Nonrandom Segregation of Parental Alleles in Reovirus Reassortants Journal of Virology. ,vol. 70, pp. 7295- 7300 ,(1996) , 10.1128/JVI.70.10.7295-7300.1996
Anthony L. Farone, Sean M. O'donnell, Chad S. Brooks, Kristel M. Young, Janene M. Pierce, J. Denise Wetzel, Terence S. Dermody, Mary B. Farone, Reovirus strain-dependent inflammatory cytokine responses and replication patterns in a human monocyte cell line. Viral Immunology. ,vol. 19, pp. 546- 557 ,(2006) , 10.1089/VIM.2006.19.546
Yasuhiro Masubuchi, Shiori Sugiyama, Toshiharu Horie, Th1/Th2 cytokine balance as a determinant of acetaminophen-induced liver injury. Chemico-Biological Interactions. ,vol. 179, pp. 273- 279 ,(2009) , 10.1016/J.CBI.2008.10.028
Jin-Yuan Fan, Christopher S. Boyce, Christopher F. Cuff, T-Helper 1 and T-Helper 2 Cytokine Responses in Gut-Associated Lymphoid Tissue Following Enteric Reovirus Infection Cellular Immunology. ,vol. 188, pp. 55- 63 ,(1998) , 10.1006/CIMM.1998.1350
Stephen C. Harris, Paul B. Watkins, Neil Kaplowitz, John T. Slattery, Connie R. Colonese, Salvatore V. Colucci, Paul W. Stewart, Aminotransferase Elevations in Healthy Adults Receiving 4 Grams of Acetaminophen Daily JAMA. ,vol. 296, pp. 87- 93 ,(2006) , 10.1001/JAMA.296.1.87
Gregory S. Smith, Daniel E. Nadig, Evan R. Kokoska, Harvey Solomon, Dina G. Tiniakos, Thomas A. Miller, Role of Neutrophils in Hepatotoxicity Induced by Oral Acetaminophen Administration in Rats Journal of Surgical Research. ,vol. 80, pp. 252- 258 ,(1998) , 10.1006/JSRE.1998.5441
C COVER, J LIU, A FARHOOD, E MALLE, M WAALKES, M BAJT, H JAESCHKE, Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity. Toxicology and Applied Pharmacology. ,vol. 216, pp. 98- 107 ,(2006) , 10.1016/J.TAAP.2006.04.010
Carol R Gardner, Jeffrey D Laskin, Donna M Dambach, Hawjyh Chiu, Stephen K Durham, Peihong Zhou, Mary Bruno, Donald R Gerecke, Marion K Gordon, Debra L Laskin, Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor receptor-1 Potential role of inflammatory mediators Toxicology and Applied Pharmacology. ,vol. 192, pp. 119- 130 ,(2003) , 10.1016/S0041-008X(03)00273-4
Kara L. Norman, Patrick W.K. Lee, Not all viruses are bad guys: the case for reovirus in cancer therapy. Drug Discovery Today. ,vol. 10, pp. 847- 855 ,(2005) , 10.1016/S1359-6446(05)03483-5