Characteristics of older and younger patients with suspected paracetamol toxicity
作者： Alice Kane , Sarah J Mitchell , Peter R Carroll , Slade Matthews , Sarah N Hilmer
DOI: 10.1111/J.1741-6612.2012.00598.X
关键词:
摘要: Aim: The aim of this study was to compare the characteristics older and younger patients with suspected paracetamol toxicity. Methods: A retrospective audit medical records (≥65 years, n= 25) (20–30 50) a detectable level at Sydney hospital. Results: Older showed different clinical pattern toxicity were more likely than have multifactorial elevation liver function tests. Additionally, age be associated chronic therapeutic dosing (71% older, 6% younger, P < 0.001), or accidental toxic exposure (90% 29% while deliberate high-dose (10% 71% 0.001). Conclusions: age-related differences in exposure, levels tests described population should considered when ordering interpreting levels.
sci-hub.se 参考文章(9)
S. J. Mitchell, S. N. Hilmer, B. P. Murnion, S. Matthews, Hepatotoxicity of therapeutic short‐course paracetamol in hospital inpatients: impact of ageing and frailty Journal of Clinical Pharmacy and Therapeutics. ,vol. 36, pp. 327- 335 ,(2011) , 10.1111/J.1365-2710.2010.01193.X
H. A. WYNNE, L. H. COPE, B. HERD, M. D. RAWLINS, O. F. W. JAMES, K. W. WOODHOUSE, The Association of Age and Frailty with Paracetamol Conjugation in Man Age and Ageing. ,vol. 19, pp. 419- 424 ,(1990) , 10.1093/AGEING/19.6.419
Jane F. Maddox, Chidozie J. Amuzie, Maoxiang Li, Sandra W. Newport, Erica Sparkenbaugh, Christopher F. Cuff, James J. Pestka, Glenn H. Cantor, Robert A. Roth, Patricia E. Ganey, Bacterial- and viral-induced inflammation increases sensitivity to acetaminophen hepatotoxicity. Journal of Toxicology and Environmental Health. ,vol. 73, pp. 58- 73 ,(2009) , 10.1080/15287390903249057
Lora E. Rikans, Danny R. Moore, Acetaminophen hepatotoxicity in aging rats. Drug and Chemical Toxicology. ,vol. 11, pp. 237- 247 ,(1988) , 10.3109/01480548809017880
E. H. Harris, Elevated Liver Function Tests in Type 2 Diabetes Clinical Diabetes. ,vol. 23, pp. 115- 119 ,(2005) , 10.2337/DIACLIN.23.3.115
Herbert L. Bonkovsky, Robert E. Kane, Dean P. Jones, Raymond E. Galinsky, Barbara Banner, Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition: evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency. Hepatology. ,vol. 19, pp. 1141- 1148 ,(1994) , 10.1002/HEP.1840190511
Frank F S Daly, John S Fountain, Lindsay Murray, Andis Graudins, Nicholas A Buckley, Guidelines for the management of paracetamol poisoning in Australia and New Zealand--explanation and elaboration. A consensus statement from clinical toxicologists consulting to the Australasian poisons information centres. The Medical Journal of Australia. ,vol. 188, pp. 296- 301 ,(2008) , 10.5694/J.1326-5377.2008.TB01625.X
Oswald Moling, Elena Cairon, Giovanni Rimenti, Francesco Rizza, Raffaele Pristerá, Peter Mian, Severe hepatotoxicity after therapeutic doses of acetaminophen Clinical Therapeutics. ,vol. 28, pp. 755- 760 ,(2006) , 10.1016/J.CLINTHERA.2006.05.002
Anne M. Larson, Acetaminophen Hepatotoxicity Clinics in Liver Disease. ,vol. 11, pp. 525- 548 ,(2007) , 10.1016/J.CLD.2007.06.006