Acetaminophen hepatotoxicity in aging rats.
作者： Lora E. Rikans , Danny R. Moore
DOI: 10.3109/01480548809017880
关键词:
摘要: Severity of liver damage 24 hr after i.p. administration acetaminophen in doses 0.4 and 0.8 g/kg was evaluated male Fischer 344 rats at 4, 14 25 months age. Both produced significant elevations serum alanine aminotransferase (ALT) sorbitol dehydrogenase (SDH) activities 4-month-old rats. Enzyme release somewhat diminished old Hepatic glutathione (GSH) microsomal cytochrome P-450 concentrations were decreased that received acetaminophen. The decreases occurred young-adult middle-aged rats, but not results demonstrated age does enhance the hepatotoxic effects
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