BIOGENIC AMINES AND THEIR METABOLISM IN THE STUDY OF AGGRESSIVE BEHAVIOUR IN RATS

摘要: Publisher Summary This chapter discusses the biogenic amines and their metabolism in study of aggressive behavior rats. Various models animal aggression may involve different central mechanisms separate neurotransmitters. Alteration serotonin with tryptophan hydroxylase inhibitor para-chlorophenylalanine induced muricide 9 34 rats when used doses ranging from 100 mg/kg to 600 mg/kg. There were no conversions vehicle-treated group. Even though there increases footshock sensitivity pCPA-treated rats, shock-induced fighting level changed insignificantly 19 26–8%. In contrast, alteration predominantly norepinephrine (NE) appears greatly affect without altering other aggression. Depletion brain dopamine damage catecholamine nerve terminals intracisternal 6-hydroxydopamine elevates shock a baseline 9.3% 37.9%. same effect can be achieved by treating intraventricular injections 6-hydroxydopa which depletes only norepinephrine.