Shock-induced aggression: Effects of 6-hydroxydopamine and other pharmacological agents
作者： Nguyen B. Thoa , Burr Eichelman , Larry K.Y. Ng
DOI: 10.1016/0006-8993(72)90401-5
关键词: Amphetamine 、 Chemistry 、 Hydroxydopamine 、 Endocrinology 、 Apomorphine 、 Aggression 、 Blockade 、 Internal medicine 、 Adrenergic 、 AMPT 、 Shock (circulatory) 、 Developmental biology 、 General Neuroscience 、 Molecular biology 、 Clinical neurology
摘要: Abstract Administration of 6-hydroxydopamine (6-OHDA) (i.c.) to rats produced a decrease in brain catecholamines (CA) and an increase footshock-induced fighting. Desmethylimipramine reduced this effect while lessening CA depletion. Blockade synthesis by either α-methylparatyrosine (AMPT) or FLA-63 did not produce any shock induced-fighting. d - l -amphetamine transiently decreased the 6-OHDA effect. -DOPA plus MK 486 effectively blocked it. Apomorphine reversed but was accompanied pronounced stereotyped behavior. The results suggest that depletion alone is sufficient facilitation shock-induced aggression. Degeneration adrenergic terminals also requisite for observed However, may be altered drugs which release CA, new or, act directly on receptor.
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sci-hub.se 参考文章(27)
B. Senault, Comportement d'agressivité intraspécifique induit par l'apomorphine chez le rat Psychopharmacology. ,vol. 18, pp. 271- 287 ,(1970) , 10.1007/BF00412673
T D Traylor, G R Breese, EFFECT OF 6-HYDROXYDOPAMINE ON BRAIN NOREPINEPHRINE AND DOPAMINE: EVIDENCE FOR SELECTIVE DEGENERATION OF CATECHOLAMINE NEURONS Journal of Pharmacology and Experimental Therapeutics. ,vol. 174, pp. 413- 420 ,(1970)
Joseph T. Coyle, Solomon H. Snyder, CATECHOLAMINE UPTAKE BY SYNAPTOSOMES IN HOMOGENATES OF RAT BRAIN: STEREOSPECIFICITY IN DIFFERENT AREAS Journal of Pharmacology and Experimental Therapeutics. ,vol. 170, pp. 221- 231 ,(1969)
K. Y. NG, T. N. CHASE, I. J. KOPIN, Drug-induced Release of 3H-Norepinephrine and 3H-Serotonin from Brain Slices Nature. ,vol. 228, pp. 468- 469 ,(1970) , 10.1038/228468A0
H. Corrodi, K. Fuxe, B. Hamberger, Å. Ljungdahl, Studies on central and peripheral noradrenaline neurons using a new dopamine-β-hydroxylase inhibitor European Journal of Pharmacology. ,vol. 12, pp. 145- 155 ,(1970) , 10.1016/0014-2999(70)90059-2
N. J. Uretsky, L. L. Iversen, Effects of 6-hydroxydopamine on catecholamine containing neurones in the rat brain. Journal of Neurochemistry. ,vol. 17, pp. 269- 278 ,(1970) , 10.1111/J.1471-4159.1970.TB02210.X
F. E. Bloom, S. Algeri, A. Groppetti, A. Revuelta, E. Costa, Lesions of Central Norepinephrine Terminals with 6-OH-Dopamine: Biochemistry and Fine Structure Science. ,vol. 166, pp. 1284- 1286 ,(1969) , 10.1126/SCIENCE.166.3910.1284
Nils-Erik Andén, Allan Rubenson, Kjell Fuxe, Tomas Hökfelt, Evidence for dopamine receptor stimulation by apomorphine Journal of Pharmacy and Pharmacology. ,vol. 19, pp. 627- 629 ,(2011) , 10.1111/J.2042-7158.1967.TB09604.X
K. Y. Ng, T. N. Chase, R. W. Colburn, I. J. Kopin, L-Dopa-Induced Release of Cerebral Monoamines Science. ,vol. 170, pp. 76- 77 ,(1970) , 10.1126/SCIENCE.170.3953.76
J. Scheel-Krüger, A. Randrup, Aggressive behaviour provoked by pargyline in rats pretreated with diethyldithiocarbamate Journal of Pharmacy and Pharmacology. ,vol. 20, pp. 948- 949 ,(2011) , 10.1111/J.2042-7158.1968.TB09680.X