Immunization with 60 kD Ro peptide produces different stages of preclinical autoimmunity in a Sjögren's syndrome model among multiple strains of inbred mice

摘要: Sjogren's syndrome is a chronic illness manifested characteristically by immune injury to the salivary and lacrimal glands, resulting in dry mouth/eyes. Anti-Ro [Sjogren's antigen A (SSA)] anti-La B (SSB)] autoantibodies are found frequently subjects as well individuals who will go on develop disease. Immunization of BALB/c mice with Ro60 peptides results epitope spreading anti-Ro along lymphocyte infiltration glands similar human Sjogren's. In addition, these animals have poor function/low saliva volume. this study, we examined whether Ro-peptide immunization produces Sjogren's-like other strains mice. BALB/c, DBA-2, PL/J, SJL/J C57BL/6 were immunized peptide-274. Sera from studied immunoblot enzyme-linked immunosorbent assay for autoantibodies. Timed flow was determined after pharmacological stimulation, pathologically. We that had no response peptide Ro60, while produced antibodies bound but spreading. PL/J structures La, like gland lymphocytic decrement function. DBA-2 only decreased The immunological processes leading interrupted stepwise fashion differing strains. These data suggest model preclinical disease genetic control spreading, glandular dysfunction.