A new animal model for primary Sjögren's syndrome in NFS/sld mutant mice.

摘要: In this study, we report an established and characterized animal model for primary Sjogren's syndrome in NFS/sld mutant mice bearing autosomal recessive gene with sublingual gland differentiation arrest. Significant inflammatory changes develop spontaneously both the salivary lacrimal glands of thymectomized 3 days after birth without any immunization, whereas no significant lesions were found other organs or nonthymectomized mice. This pathology resembles humans, which involves parotid, submandibular salivary, glands. A significantly higher incidence autoimmune was female mice, anti-salivary duct autoantibodies detected sera from but not control The infiltration into consisted mainly CD3+ CD4+ T cells, a lesser proportion CD8+ cells B220+ B during course disease. When repertoire TCR V beta genes transcribed expressed within infiltrates analyzed lesions, considerable preferential use (V 8 predominant) these onset Thus, can propose newly developing strain Moreover, predominant patterns transcript expression may be somewhat restricted, suggesting that TCR-based immunotherapy is possible.