CHAPTER 31 – Sjögren Syndrome

摘要: Publisher Summary Sjogren syndrome (SS) is an autoimmune disorder characterized by exocrine gland dysfunction and destruction, mainly the salivary lachrymal glands, leading to dryness of mouth eyes. Sjogren has been long regarded as disease, due presence lymphoid infiltrates in plethora serum autoantibodies, various hyperimmune clinical complications, well its frequent association with other disorders. Exocrinopathy associated dense lymphocytic glandular tissues B-cell hyper-reactivity. appears unique for two reasons. First, it a broad presentation, extending from local exocrinopathy involvement multiple organs. It may be found alone, primary SS or diseases, secondary SS. Although clinical, serologic, genetic features distinguish SS, remains unclear whether these entities are etiologically pathogenically different. Second, model where benign process can evolve into malignancy. Thus, study provide insights pathogenesis disorders