Activation of epithelial and myoepithelial cells in the salivary glands of patients with Sjögren's syndrome: high expression of intercellular adhesion molecule-1 (ICAM.1) in biopsy specimens and cultured cells.

摘要: ICAM.1 (CD54) is a surface protein expressed on epithelial and other nonhematopoietic cells upon activation known to play an important role in the stimulation of T by provision cellular adhesion costimulatory support. Sjogren's syndrome (SS) autoimmune exocrinopathy, which characterized chronic lymphocytic infiltration exocrine glands aberrant tissues. To address contribution pathogenesis SS, expression this was studied immunohistochemistry flow cytometry minor salivary gland (SG) biopsies as well cultured SG cell (SGEC) lines obtained from 18 SS patients 16 controls. In (but not controls), strong infiltrating mononuclear (52%) significant proportion periacinar myoepithelial (18%). addition, patchy pattern moderate detected 31% ductal epithelia patients. These ICAM.1-expressing were observed throughout glandular tissues confined areas proximal lymphoid infiltrates. support intrinsic profile SGEC long-term non-neoplastic derived displayed significantly upregulated spontaneous ICAM.1, compared controls (P < 0.05). The high epithelium likely suggestive its disorder. Further, our results model whereby these actively participate induction maintenance infiltrates