Growth Hormone (GH) Dose-Response in Young Adults with Childhood-Onset GH Deficiency: A Two-Year, Multicenter, Multiple-Dose, Placebo-Controlled Study

摘要: GH replacement therapy has been shown to improve abnormalities in body composition, bone mineral density (BMD), lipid profile, and other changes resulting from deficiency (GHD) adults. There is, however, need determine appropriate dosing young adults who were treated for GHD as children, bridge the interval between childhood (in which relatively high doses are used) older adulthood only lower tolerated). This multicenter, randomized, double-blind, placebo-controlled study compares safety efficacy of two (25 12.5 μg/kg·d) with placebo, maintained 2 yr, children off at least 1 yr (mean, 5.6 yr). The 64 subjects less than 35 age 23.8 yr) had maximum serum responses, on retesting 5 μg/liter 0.7 μg/liter). At baseline, 22% spine BMD below −2 sd, 59% overweight or obese, 45% total cholesterol more 200 mg/dl. A sign...