High Susceptibility of Obese Hypertensive SHRSP.Z-Leprfa/IzmDmcr Rats to Lipid Deposition in the Mesenteric Artery

摘要: 1. Atherosclerosis is commonly observed in obesity. Obese atherosclerosis-prone animals may be a promising tool for understanding the pathophysiology of obesity-associated atherosclerosis. However, most rat strains are resistant to The aim present study was assess susceptibility two obese hypertensive models, namely SHRSP.Z-Lepr(fa) /IzmDmcr rats (SHRSP-fatty) and SHR.Cg-Lepr(cp) /NDmcr (SHR-cp), arterial lipid deposition, an initial stage atherosclerosis, by comparing these with non-obese stroke-prone spontaneously (SHRSP). 2. Eight-week-old male SHRSP, SHRSP-fatty SHR-cp were fed high-fat high-cholesterol diet containing 20% palm oil, 5% cholesterol 2% cholic acid 5weeks. Bodyweight, blood pressure fasting serum levels total triglycerides measured 12-week-old rats. Oil red O staining used visualize deposition mesenteric artery. 3. bodyweight higher than that SHRSP (P<0.005). Systolic Serum triglyceride elevated (P<0.005) (P<0.05) compared SHRSP. Lipid artery significantly greater (37.7±4.9 vs 13.1±2.8%, respectively; P<0.005), but markedly reduced (1.8±0.4%; P<0.05). 4. results indicate highly susceptible whereas resistant. Thus, useful model which investigate atherosclerotic processes.