A High-Fat and High-Cholesterol Diet Induces Cardiac Fibrosis, Vascular Endothelial, and Left Ventricular Diastolic Dysfunction in SHRSP5/Dmcr Rats.

摘要: AIM Non-alcoholic steatohepatitis (NASH) increases cardiovascular risk regardless of factors in metabolic syndrome. However, the intermediary between NASH and vascular disease are still unknown because a suitable animal model has never been established. The stroke-prone (SP) spontaneously hypertensive rat, SHRSP5/Dmcr, simultaneously develops hypertension, acute arterial lipid deposits mesenteric arteries, when feed with high-fat high-cholesterol (HFC) diet. We investigated whether SHRSP5/Dmcr affected aggravates cardiac or dysfunction. METHOD Wister Kyoto rats were divided into 4 groups 5 each, fed SP HFC After 8 weeks diet feeding, glucose insulin resistance, echocardiography, blood biochemistry, histopathological staining, endothelial function aorta evaluated. RESULTS demonstrate that presented dysfunction caused by fibrosis, dysfunction, left ventricular diastolic association hypertension. These dysfunctions aggravated not associated presence metabolism disorder, and/or obesity. CONCLUSIONS may be for elucidating organ interaction