APOE-ε2 and APOE-ε4 correlate with increased amyloid accumulation in cerebral vasculature.

摘要: The APOE e4 allele correlates with increased risk of Alzheimer disease (AD) and parenchymal amyloid plaques. We tested how the genotype correlated cerebral angiopathy (CAA) by analyzing 371 brains for meningeal CAA in 4 brain regions (frontal, parietal, temporal, occipital neocortex). overall severity was highest lobe. APOE-e4/4 (n = 22) had levels across regions. In lobe, nearly all cases were scored level (meninges, 95% cases; parenchyma, 81%). this region as others, APOE-e3/4 115) showed consistently less that 43%; 43%). APOE-e3/3 182) even 19%; 19%). Interestingly, APOE-e2/3 42) more than 44%; 32%), despite a reduced AD individuals. also fewest without CAA, whereas most. Ordinal regression analyses demonstrated significant impacts APOE-e2 APOE-e4 on at least some region. These data demonstrate correlations Ab deposition only incompletely correspond to other AD-linked pathologies.