Some clinical pharmacological studies with terfenadine, a new antihistamine drug.

摘要: 1 A double-blind cross-over trial between placebo, chlorpheniramine, and terfenadine, a new antihistamine drug, was performed in healthy male volunteers to determine compare their CNS autonomic effects. 2 Terfenadine chlorpheniramine were administered orally therapeutic doses. 3 In objective tests of critical flicker frequency, pursuit rotor, reaction time, salivary volume pupillary diameter, no statistically significant difference observed the treatments. 4 On analogue rating scales, produced (P less than 0.05) degree sedation impaired concentration as compared placebo terfenadine. 5 The results obtained scales not normally distributed and, therefore, use non-parametric statistical methods for analysis such data is strongly advocated.