Single and repeated dose comparison of three antihistamines and phenylpropanolamine: psychomotor performance and subjective appraisals of sleep.

摘要: 1 In a double-blind cross-over study, nine healthy male students received placebo, brompheniramine 12 mg), carbinoxamine (12 clemastine (1 and phenylpropanolamine (50 mg) orally. Three doses of each drug were given: at 08.30 h 21.00 on the first day treatment following day. 2 Psychomotor skills subjective feelings recorded before 2, 6 after dose as well third 2. Subjective appraisals sleep requested morning 3 All antihistamines tended to cause drowsiness treatment. Drowsiness was felt for maximum carbinoxamine, brompheniramine, clemastine. contrast antihistamines, made subjects more alert quick witted. Tolerance antihistamine-induced developed second 4 Divided attention, tracking, speed anticipation not affected by any drug. Carbinoxamine slowed reactions dose, but no impairment measured in objective tests or 5 Phenylpropanolamine improved reaction accuracy enhanced flicker recognition throughout study. plasma levels improvement fusion test results correlated with other The suggest that studied are comparatively harmless psychomotor performance driving skills.