Performance studies with antihistamines.
作者： CH Clarke , AN Nicholson
DOI: 10.1111/J.1365-2125.1978.TB01678.X
关键词:
摘要: 1 Effect of four antihistamines, chlorpheniramine (4 mg), clemastine (1 promethazine (10 mg) and terfenadine (60 on visuo-motor coordination subjective assessments performance well-being were compared with placebo in six healthy females from 0.5--7.0 h after morning ingestion each drug. The study was double-blind, the doses used believed to be equally potent their antihistaminic activity. 2 There impaired 1.5 (P less than 0.01) chlorpheniramine, 3.0 0.05) 5.0 clemastine, 0.001) promethazine. It not possible establish effects terfenadine. Subjective altered. 3 subjects as a group reported improved alertness wakefulness 0.5 3.5 respectively terfenadine, energetic 7.0 chlorpheniramine. other consistent changes well-being.
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