Cytolytic toxins from gram-negative bacteria.

摘要: Many Gram-negative bacterial pathogens synthesize cytolytic toxins as virulence factors. Most of these generate pores in eukaryotic cell membranes, but there are apparently several different mechanisms pore formation. Cytolysins bacteria usually synthesized precursor proteins which converted to the active by modification or proteolytic processing. Such a requirement for activation is not common cytolysins produced Gram-positive bacteria. The extracellular secretion from depends on specific transport systems.