Proanthocyanidins from cinnamon and its water soluble extract inhibit tau aggregation

作者: Donald J. Graves , John Lew

DOI:

关键词: ChemistryBiochemistryProanthocyanidinTau isoformsCinnamomumWater soluble

摘要: Compositions comprising proanthocyanidin compositions (e.g. those extracted from cinnamomum species) that are observed to bind tau and inhibit its aggregation as well methods for making using such disclosed. In certain embodiments of the invention, proanthocyanidins can be used a probe identify and/or characterize isoforms in variety contexts. other these designed treat neurological disorders associated with Alzheimer's disease).

参考文章(6)
Patricia Carol Edwards, Martin Roth, Charles Robert Harrington, Claude Michel Wischik, Aaron Klug, Screening methods for agents that modulate or inhibit tau association with tau or map2 ,(1996)
Masami Masuda, Nobuyuki Suzuki, Sayuri Taniguchi, Takayuki Oikawa, Takashi Nonaka, Takeshi Iwatsubo, Shin-ichi Hisanaga, Michel Goedert, Masato Hasegawa, Small Molecule Inhibitors of α-Synuclein Filament Assembly† Biochemistry. ,vol. 45, pp. 6085- 6094 ,(2006) , 10.1021/BI0600749
Louis Danoux, Gilles Pauly, Florence Henry, Use of oligomeric proanthrocyanidins ,(2002)
Geraldo M Castillo, Beth P Nguyen, Alan D Snow, Paula Y Choi, Proanthocyanidins for the treatment of amyloid and alpha-synuclein diseases ,(2002)
Gen-ichiro Nonaka, Satoshi Morimoto, Itsuo Nishioka, Tannins and related compounds. Part 13. Isolation and structures of trimeric, tetrameric, and pentameric proanthicyanidins from cinnamon Journal of The Chemical Society-perkin Transactions 1. ,vol. 14, pp. 2139- 2145 ,(1983) , 10.1039/P19830002139