Tau aggregation inhibitor
作者： Yuki Shinzaki , Tomohiro Miyasaka , Yoshiyuki Soeda , Hachiro Sugimoto , Yasuo Ihara
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摘要: A tau aggregation inhibitor can sufficiently inhibit a protein from aggregating in cells. The includes 4-substituted catechol structure compound, having, at position 4 of its ring, an electron-donating substituent R other than hydrocarbon group, or salt thereof. compound is preferably 4-aminocatechol 1,2,4-benzenetriol. Examples tauopathies to which this applicable include AD, Down's syndrome, frontotemporal dementia, cotricobasal degeneration (CBD) and progressive supranuclear palsy (PSP).
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