Review: Advances in methodology of DNA methylation assay

作者: Tian Tian , ShaoRu Wang , JianGuo Wu , Xiang Zhou

DOI: 10.1007/S11426-011-4318-7

关键词: Molecular biologyDNA methylationIllumina Methylation AssayBiologyEpigenomicsChromatinMethylationMethylated DNA immunoprecipitationRNA-Directed DNA MethylationComputational biologyEpigeneticsGeneral chemistry

摘要: DNA methylation is one of the most signaficant epigenetic events which greatly influence gene activation, imprinting, chromatin stability, and so on. The level in genome certain regions should be a normal range, because any variation would cause physiological dysfunction. In account essential roles living system, detection both overall specific positions has drawn great interest. So far many biological chemical methods have been developed to detect methylation. Herein, we summerize some novel mainly based on modification analytic detection.

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