The importance of mitochondrial folate enzymes in human colorectal cancer

摘要: Abstract Folate plays a pivotal role in the one-carbon metabolism needed for methylation reactions, nucleotide synthesis, and DNA repair. Although folate was recently shown to be associated with carcinogenesis some solid tumors, importance of colorectal cancer remains unclear. In present investigation we found that expression three mitochondrial metabolic enzymes, serine hydroxymethyl transferase (SHMT2), methylenetetrahydrofolate dehydrogenase (MTHFD2) aldehyde dehydrogenase 1 family member L2 (ALDH1L2), were upregulated human tumor tissues compared normal tissues. Colorectal tissue samples obtained from 117 consecutive patients. We evaluated enzymes immunohistochemical analysis determined their relevance clinicopathological characteristics prognosis. Rates recurrence-free survival (RFS) overall survival (OS) patients high SHMT2, MTHFD2 ALDH1L2 tended lower than low (P=0.446 P=0.337, P=0.099 P=0.064, P=0.178 P=0.257, respectively). Notably, combined (triple high) more highly poor prognosis individual levels (RFS; P=0.004 OS; P=0.037). A multivariate showed triple independently RFS (P=0.017). These findings suggested could provide potential therapeutic strategy treating cancer.