作者: Masatoshi Kiuchi , Maiko Hamada , Mitsuharu Nakamura , Kunio Sugahara
DOI:
关键词: Stereochemistry 、 Hydrogen atom 、 Alkyl 、 Chemistry 、 Halogen 、 Arylene 、 Phenylene 、 Aryl 、 Hydrate 、 Phenyl group 、 Medicinal chemistry
摘要: [PROBLEMS] To provide a novel compound having few adverse side-effects such as bradycardia and also an excellent effect of reducing the number lymphocytes in peripheral blood. [MEANS FOR SOLVING PROBLEMS] Disclosed is 2-aminobutanol represented by general formula (I) shown below, pharmaceutically acceptable acid addition salt thereof, or hydrate solvate salt. Also disclosed process for production compound. wherein R1 represents hydrogen atom P(=O)(OH)2; R2 analkyl 1 to 4 carbon atoms which may be substituted hydroxyl group halogen atom; R3 atom, cyano, alkyl acyl 2 5 subsituted X oxygen sulfur carbonyl NR4 (wherein R4 atoms; Ar1 arylene heteroarylene substituted; Ar2 aryl hateroaryl subsituted, provided that, when phenylene phenyl group, corresponding substituted.