2-aminobutanol compound and use thereof for medical purposes

作者: Masatoshi Kiuchi , Maiko Hamada , Mitsuharu Nakamura , Kunio Sugahara

DOI:

关键词: StereochemistryHydrogen atomAlkylChemistryHalogenArylenePhenyleneArylHydratePhenyl groupMedicinal chemistry

摘要: [PROBLEMS] To provide a novel compound having few adverse side-effects such as bradycardia and also an excellent effect of reducing the number lymphocytes in peripheral blood. [MEANS FOR SOLVING PROBLEMS] Disclosed is 2-aminobutanol represented by general formula (I) shown below, pharmaceutically acceptable acid addition salt thereof, or hydrate solvate salt. Also disclosed process for production compound. wherein R1 represents hydrogen atom P(=O)(OH)2; R2 analkyl 1 to 4 carbon atoms which may be substituted hydroxyl group halogen atom; R3 atom, cyano, alkyl acyl 2 5 subsituted X oxygen sulfur carbonyl NR4 (wherein R4 atoms; Ar1 arylene heteroarylene substituted; Ar2 aryl hateroaryl subsituted, provided that, when phenylene phenyl group, corresponding substituted.

参考文章(9)
Walter Märki, Dominik Imfeld, Peter Fürst, Patrick Schindler, Polypeptides involved in the staurosporine induced apoptotic pathway ,(1998)
Klaus Hinterding, Yuan Mi, Nathanael S. Gray, Lawrence Blas Perez, Peter Ettmayer, Shifeng Pan, Federic Zecri, Wei Wang, Peter Nussbaumer, Kenneth Richad la Montagne, Wenqui Gao, Fan Yi, Sophie Lefebvre, Bis-aromatic alkanols ,(2003)
Kenji Yoshitomi Pharmaceutical Ltd. Chiba, Koji Yoshitomi Pharmaceutical Ind. Ltd. Teshima, Tetsuro Fujita, Tadashi Yoshitomi Pharmaceutical Ltd. Mishina, Toshiyuki Yoshitomi Pharmaceutical Ind.Ltd. Kohara, Masatoshi Yoshitomi Pharmaceutical Ind.Ltd. Kiuchi, Kunitomo Yoshitomi Pharmaceutical Ind Ltd. Adachi, Benzene compound and medicinal use thereof ,(1995)
Shinji Kudou, Satoru Iwanami, Naoki Ando, Takahiro Tanase, Kazuhiko Kuriyama, Yasushi Kohno, Diaryl ether derivative, addition salt thereof, and immunosuppressant ,(2002)
Mehrdad Matloubian, Charles G. Lo, Guy Cinamon, Matthew J. Lesneski, Ying Xu, Volker Brinkmann, Maria L. Allende, Richard L. Proia, Jason G. Cyster, Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1 Nature. ,vol. 427, pp. 355- 360 ,(2004) , 10.1038/NATURE02284
Shigeo Sasaki, Masahiko Yoneta, Tetsuro Fujita, Tadashi Yoshitomi Pharmac. Ind. Ltd. Mishina, Kunitomo Yoshitomi Pharmac. Ind. Ltd. Adachi, Kenji Yoshitomi Pharmac. Ind. Ltd Chiba, 2-amino-1,3-propanediol compound and immunosuppressant ,(1993)
Suzanne Mandala, Richard Hajdu, James Bergstrom, Elizabeth Quackenbush, Jenny Xie, James Milligan, Rosemary Thornton, Gan-Ju Shei, Deborah Card, CarolAnn Keohane, Mark Rosenbach, Jeffrey Hale, Christopher L Lynch, Kathleen Rupprecht, William Parsons, Hugh Rosen, Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science. ,vol. 296, pp. 346- 349 ,(2002) , 10.1126/SCIENCE.1070238
Naoki Ando, Kazuhiko Kuriyama, Yasushi Kohno, Shinji Kudou, Satoru Iwanami, Diaryl sulfide derivative, addition salt thereof, and immunosuppressant ,(2002)
Satoru Iwanami, Kazuhiko Kuriyama, Takayuki Sawada, Yasushi Kono, 和彦 栗山, 尚基 安藤, Naoki Andou, 靖志 河野, 孝之 澤田, 哲 岩浪, 2-amino-1,3-propanediol derivative and its addition salt ,(2003)